Wanting to go legit a young drug dealer must do one last run to rescue her sister being held hostage by her boss; knowing she be going to be killed.

“She suspects that she is being sent to her own death.”
My point is, what is so different? The risk seems to be the same as she is used to. Instead suspecting, I am suggesting you make it so that she knows that her boss wants her dead. That her boss wants to take something from her. And to save her sister, she is willing to give it up; she is sacrificing something so her sister can live.
To continue with my earlier example, say the boss outright tells her, “one of the people you’re working with is an undercover cop/mole”, which tells her that either this job is a complete suicide mission so get rid of two birds with one stone, or she’ll get put away because of the mole.
If she suspects, it doesn’t seem to be that different from past runs; she would probably be paranoid about someone ratting her out, or something going bad and her ending up dead/injured. If the job does not look any different than before, then there are fairly low stakes. She simply does the thing she has done, presumably without capture, once again, and then her sister is set free.
To sum it up with one question: What makes the actual job(meaning other than the sister) different from before?

“Maybe she needs to do a run in or out of Saudi Arabia? Or North Korea? Or China?”
Yes, I didn’t think about that. Maybe a different twist to think about is that the authorities know. The boss literally tells her pointblank: I notified the authorities of your future activity. Have fun!
Then the drug runner has to come up with an even more creative way to sneak past them.
To help you along, I looked up a?personal experience article from an actual drug runner(yes, I know is it?from a comedy site, so take any facts within it with a grain of salt). And, from the same site(again, check any facts with other sources, but you should always do that anyway), an article detailing some creative techniques. Another from a different site.
Hope this helps.

‘?The world is a better place without me in it?.”
Who’s going to take care of her sister? Are the parents still around? Because if not, Amy letting herself die is just leaving her 13 year old sister to fend for herself.

I still think you need a better reason for the boss kidnapping the sister. Because it sounds like Amy doesn’t know her boss suspects her. So why would he show his hand and do something like kidnapping her sister? If she were working the cops, then all she has to do is tell them he has her sister, and bam, a kidnapping charge, whether or not they can get him on anything else.
So I think the one thing you need to think about is giving Doug a solid reason for kidnapping the sister.
As for reading your script, I would but I haven’t been finding the time to read lately because I am working on writing my own script and planning a novel.

On a last note, has anyone else been on the Amazon Studios program? It seems like a really cool option for screenwriters.

“The core dramatic question raised by the logline is: ?can Amy rescue her sister?”

Agreed with dpg. What is the point of the story at all if her sister can simply rescue herself? The audience goes, expecting to see Amy go through whatever it is she goes through in order to save her sister, but then comes to find out that her whole journey was pointless.
There would be cases where Amy not saving her sister were acceptable. Say if her arc was learning to trust others, and then she finally allows someone to help her and save her sister; then that would be a part of Amy’s development. She trusted someone else to complete the mission she set out to do.
What do we get if Ella saves herself? Nothing. No development. No feeling of triumph when the protagonist defeats the ?antagonist. ?Amy doesn’t even know. ?And then Amy sacrifices herself, for what?

“Amy believed originally that she would visit Doug, spin some crap to buy a day or two and leave. Instead, he grabbed Ella and triggers the events.”

Doug still has the advantage in the fact that Amy doesn’t know he suspects her. I still don’t think it’s very smart of him to play his hand and kidnap a girl based on suspicion alone. It’s not even a part of some elaborate plan to prove Amy is working against him. He just kidnaps her so the story can happen.
And, still, Ella rescuing herself serves nothing. It’s like you’re painting yourself into a corner by making Amy’s task too impossible so you finish the goal by making Ella get away.
It would make more sense if Doug catches Amy about to take her sister and run, and then it makes his suspicion valid and out of anger he snatches her sister and then uses that to leverage Amy into doing more work. And all along Amy is plotting to rescue her sister.

“If you do not want Amy to directly rescue her sister from the clutches of the drug dealer, then I suggest you need to revise the logline to eliminate that expectation. ?Otherwise it is misleading.Just saying.”

Agree. What is the story really about? What is the action which causes everything else in the story? Is it Amy wanting to go legit or is it Amy wanting to save her sister?

“?Her only chance is with her ex-girl friend who has gone legit. For this to happen Amy must die.”

I still don’t see exactly why Ella is kidnapped. It’s only a noticeable crime that will have consequences for Doug. There is no motive to kidnap the sister. The very thing he’s trying to prevent is bringing attention to himself by making sure Amy isn’t an informant, which again, why would he kidnap someone based on a suspicion? But he’s bringing unwanted attention….in order to prevent unwanted attention?
And why must Amy die? If Doug knows about her sister, she is not safe. Amy dying only leaves her sister without her protection.
If Ella frees herself and then Amy just dies for the heck of it, it has no impact. The goal already complete, and unless it’s for setting up a sequel, the death is extraneous. It is not earned. Amy did not die because of a complete dedication to her goal, which was already complete. It was because after the fact she got the idea that her sister’s life would be better without her. It doesn’t really develop her character, it serves nothing.

If the story is about a woman trying to go legit after a life of crime, so she give her sister a better life, then focus on that.

Example:?When her sister is shot by a rival gang, a drug runner must steal enough money from her drug boss to get out of a life of crime and protect her sister.?(~32 words)

This focuses on that: Amy realizing what her life is doing to her sister, and now she must do something to get away from it.