Who is the antagonist and what is his motive?

Who is the protagonist? If not the girl you must decide who it will be.
The information is all there but the order in which you present your logline could be better. Start with the prophetic pregnancy (inciting incident) and go to the outcome of it and the conflict stuff. By the way, who are these supernatural factions?

He wakes up out of his coffin, or he wakes up and gets out?
How does he end up leading the revolt? If he uses his powers of persuasion people will know who he is… besides he only gets out at night. Why is he trying to conceal his identity? Does he conceal it from his revolutionary partners?
What triggered his awakening?
When you say “take them down” you should be more specific: the oligarchy, the party, the president and his goons!? Who is the main antagonist? the police chief, the guy in charge?

Who’s the protagonist?
The goal and conflict is not clear.
Who are these people? What kind of show is this?
Fiction or reality TV?
How do they enter the psyche of the viewers?
What’s the genre?

Sounds like a short movie, or a theater piece… Use the plural in sisters… How many sisters?
Is this a post-human species or just a group of aliens? Are they organic beings?
What is their interest in humans? Are they scientists or is this just a casual conversation?
What kind of society are we talking about?
Do they have contrasting opinions about humans? You need conflict…
If it is a comedy you should present something that indicates the genre in your logline.

Cool. This could work as a comedy as well.

Don’t start with the doctor, start with the protagonist and give a bit more info on this guy. Who is he?
Ex.: When a popular recent grad finds out he has just one month to live, he and his best friend will check everything off his bucket list.
Is he the popular guy, the nerd, the athletic? What kind of list are we talking about? Is this a comedy or a drama?

…unleashing their narcotic…

What kind of narcotic are we talking about and why will “everyone” use it and become addicted? Is it in the food? In the water?

Your logline is a bit difficult to read/ understand at first. You should re-write it. Use the formula: When [a major event happens], [the hero], must [do the main action].

Ex.: When a group of assassins finds out they have bombs placed inside their bodies they will race against time to discover the key that prevents them from exploding…

He inherits his powers? from who? Is he special or was it by luck? What kind of supernatural powers? Why do you say they are supernatural? Why and when does he decide to become a vigilante? Are you aiming at comedy when you say the rainy city of Seatle will become a fiery hell or does this have to do with the supernatural stuff? Is Lucifer involved? Why fire?